The Practice Of Medicinal Chemistry

The Practice of Medicinal Chemistry PDF
Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 012417213X
Size: 50.80 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 902
View: 7393

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Book Description: The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

The Practice Of Medicinal Chemistry

The Practice of Medicinal Chemistry PDF
Author: C. G. Wermuth
Publisher: Elsevier
ISBN: 0127444815
Size: 42.21 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 768
View: 4139

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Book Description: Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimising pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications. This is the second edition of The Practice of Medicinal Chemistry, the first edition being published in February 1996. The new edition is thoroughly revised, with around 30% new material, and refocussed to reflect the recent developments in genomics, proteomics, high throughput screening of compounds and drug solubilisation. An effort has been made to remove the overlap that exists in the previous edition and four new chapters have been introduced. * Written by experts in the field * The first edition of The Practice of Medicinal Chemistry, published in 1996, was nicknamed 'The Bible' by medicinal chemists. * The only available book dealing with the practical aspects of medicinal chemistry, from conception of the molecules through to the production of drugs * An essential practical handbook for the medicinal chemist, working in the pharmaceutical industry, with little or no background in medicinal chemistry-a complete guide to the drug discovery process.

The Practice Of Medicinal Chemistry

The Practice of Medicinal Chemistry PDF
Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 0080497772
Size: 53.71 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 736
View: 994

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Book Description: The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. * The only book available dealing with the practical aspects of medicinal chemistry * Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production * Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry

Medicinal Chemistry

Medicinal Chemistry PDF
Author: Frank D. King
Publisher:
ISBN:
Size: 43.26 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 448
View: 4315

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Book Description: This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.

The Handbook Of Medicinal Chemistry

The Handbook of Medicinal Chemistry PDF
Author: Andrew Davis
Publisher: Royal Society of Chemistry
ISBN: 1782621830
Size: 61.63 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 753
View: 3187

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Book Description: Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

The Chemical Gazette Or Journal Of Practical Chemistry In All Its Applications To Pharmacy Arts And Manufactures

The Chemical Gazette  Or  Journal of Practical Chemistry  in All Its Applications to Pharmacy  Arts  and Manufactures PDF
Author:
Publisher:
ISBN:
Size: 32.79 MB
Format: PDF, Docs
Category : Chemistry
Languages : en
Pages :
View: 4215

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Book Description:

The Chemical Gazette

The Chemical Gazette PDF
Author:
Publisher:
ISBN:
Size: 75.51 MB
Format: PDF, ePub, Mobi
Category : Chemistry
Languages : en
Pages :
View: 3704

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Book Description:

Current Medicinal Chemistry

Current Medicinal Chemistry PDF
Author:
Publisher:
ISBN:
Size: 38.58 MB
Format: PDF
Category :
Languages : en
Pages : 94
View: 563

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Book Description:

Comprehensive Medicinal Chemistry Ii

Comprehensive medicinal chemistry II PDF
Author: John B. Taylor
Publisher: Elsevier Science Ltd
ISBN:
Size: 64.51 MB
Format: PDF
Category : Computers
Languages : en
Pages : 7200
View: 2960

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Book Description: The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Pharmaceutical Organic Chemistry

Pharmaceutical Organic Chemistry PDF
Author: V. Alagarsamy
Publisher: BSP Books
ISBN: 9389354781
Size: 65.46 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 768
View: 5253

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Book Description: Pharmaceutical organic chemistry is the main branch of organic chemistry deals with the study of preparation, structure and reactions of organic compounds. As it deals with all the chemical reactions related to life, study of Pharmaceutical organic chemistry is important. Application of Organic chemistry in the development of pharmaceuticals, resulted in evolving Pharmaceutical organic chemistry. Hence studying Organic chemistry and applying this knowledge in Pharmaceutical substances is called as Pharmaceutical organic chemistry. Organic chemistry forms the basis of biochemistry, in which various aspects of health and diseases are studied. The biochemical knowledge is very important for the practice of nutritional, medical and related life sciences. In addition Organic chemistry paved way for the development of medicinal chemistry, Pharmaceutical organic chemistry, bioinformatics, biotechnology, gene therapy, Pharmacology, pathology, chemical engineering, dental science and so on. Organic substances play such a vital role in our daily life that all of us should know about organic chemistry in order to understand the manner how it influence our life process.