Pancreatic Beta Cell In Health And Disease

Pancreatic Beta Cell in Health and Disease PDF
Author: Susumu Seino
Publisher: Springer Science & Business Media
ISBN: 9784431754527
Size: 29.68 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 476
View: 5661

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Book Description: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

The Pancreatic Beta Cell

The Pancreatic Beta Cell PDF
Author: Gerald Litwack
Publisher: Academic Press
ISBN: 9780128001745
Size: 40.36 MB
Format: PDF, Mobi
Category : Science
Languages : un
Pages : 520
View: 5194

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Book Description: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. Key features: Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels Three-dimensional structures in color Elaborate signaling pathways

Glucose Sensing Receptor In Pancreatic Beta Cells

Glucose sensing Receptor in Pancreatic Beta cells PDF
Author: Itaru Kojima
Publisher: Springer
ISBN: 981130002X
Size: 71.87 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : un
Pages : 71
View: 2819

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Book Description: Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.” This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.

Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes

Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes PDF
Author: David J. Hill
Publisher: Bentham Science Publishers
ISBN: 1681083655
Size: 16.41 MB
Format: PDF, Docs
Category : Science
Languages : un
Pages : 245
View: 5907

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Book Description: Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.

Biophysics Of The Pancreatic Cell

Biophysics of the Pancreatic    Cell PDF
Author: Illani Atwater
Publisher: Springer Science & Business Media
ISBN: 1468453149
Size: 17.73 MB
Format: PDF, ePub, Docs
Category : Science
Languages : un
Pages : 494
View: 3060

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Book Description: Pancreatic a-cell biophysics has undergone a veritable informa tion explosion in the past two years. Single channel and macroscopic currents have become easily accessible following the introduction of the patch clamp technique. In addition to this new approach, further development of techniques for optical measurements, ion-sensitive microelectrodes, permeabilized cells and mathematical modelling have recently added to the now classical techniques of membrane potential recording and tracer flux measurement. The International Workshop on Biophysics of the Pancreatic a-Cell held in Alicante (Spain) on Sep tember 30 - October 1, 1985, has now given us the opportunity to share experiences with these new techniques applied to the a-cell. Further more this was the first occasion for most of the groups doing patch clamp studies of the a-cell to decide on appropriate nomenclature and to debate the different characteristics of the a-cell ionic channels. To make this information available to the larger scientific community a record of the meeting has been assembled in this book. It is a collection of research papers by leading scientists at the meet ing working on biophysical, biochemical and physiological aspects. of secretion. We grouped their contributions in seven sections, includ ing new experimental approaches, K-channels, Ca-channels, role of ionic channels, intracellular ionized calcium, neural regulation and mechanisms of insulin release. Each section gives an account of the state of the problem at the time of the meeting, and the subjects are analyzed from the different perspectives of the various contributors.

The Islets Of Langerhans

The Islets of Langerhans PDF
Author: Md. Shahidul Islam
Publisher: Springer Science & Business Media
ISBN: 9048132711
Size: 28.82 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 798
View: 1398

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Book Description: When new fellows join my lab, I give them some reading materials so that they can orient themselves in their assignment in a new eld. When fellows leave my lab, some after writing their dissertations, I prefer to give them a book as a symbolic present. I was longing for a book that contained something on more or less eve- thing about the islets. At the same time, I wished it contained information as recent as possible. There are a few such books in the market but they are pretty outdated. I started picking islets myself from October 1990, when I joined the Rolf Luft Center, Karolinska Institutet. Over the years my fascination for islet research remained high. Since last year, I felt a stronger urge to do more for these mysterious and hidden mini-organs that are directly or indirectly involved in the pathogenesis of all forms of diabetes that affects ?250 million people in the world. After I launched the Islet (landesbioscience. com/journals/islets) and founded the Islet Society (isletso- ety. org), there was a momentum that could be utilized to create something equally meaningful i. e. this book. The idea cracked in September 2008. Starting September 19, 2008, I contacted an estimated 90% of the authors who published anything on the islets during 2007–2008 and who could be traced from the internet.

Growth And Function Of The Pancreatic Cell In Vitro

Growth and function of the pancreatic    cell in vitro PDF
Author: Jens Høiriis Nielsen
Publisher:
ISBN: 9788774942801
Size: 34.59 MB
Format: PDF, Mobi
Category : Glucose
Languages : un
Pages : 39
View: 4787

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Book Description:

Pancreatic Beta Cell In Health And Disease

Pancreatic Beta Cell in Health and Disease PDF
Author: Susumu Seino
Publisher: Springer
ISBN: 9784431800750
Size: 40.56 MB
Format: PDF, ePub, Docs
Category : Science
Languages : un
Pages : 476
View: 2915

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Book Description: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

Immunopathogenesis And Immune Based Therapy For Selected Autoimmune Disorders

Immunopathogenesis and Immune based Therapy for Selected Autoimmune Disorders PDF
Author: Mourad Aribi
Publisher: BoD – Books on Demand
ISBN: 9535130218
Size: 42.35 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 182
View: 7258

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Book Description: The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.

A Modern Epidemic

A Modern Epidemic PDF
Author: Louise Baur
Publisher: Sydney University Press
ISBN: 1920899855
Size: 31.47 MB
Format: PDF, ePub, Mobi
Category : Diabetes
Languages : en
Pages : 432
View: 4747

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Book Description: Diabetes, obesity and their related diseases make up one of the greatest challenges to human health in the 21st century. In A modern epidemic: expert perspectives on obesity and diabetes, a diverse group of researchers and clinicians from the University of Sydney has joined forces to discuss how to tackle these major health challenges.