Perfect Targets

Perfect Targets PDF
Author: Rebekah Heinrichs
Publisher: AAPC Publishing
ISBN: 9781931282185
Size: 29.97 MB
Format: PDF, ePub
Category : Family & Relationships
Languages : en
Pages : 189
View: 2068

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Book Description: A 2002 study from Comprehensive Issues in Pediatric Nursing found that 94 percent of students with Asperger Syndrome face torment from their peers. Indeed, some of their behaviors and characteristics that others see as "different" make many of these children easy targets for frequent and severe bullying. This book takes a frank look at the different types of bullying and what adults must do to curb bullying, helping prevent the often lifelong effects of this behavior on its victims. Practical strategies and solutions at the school, class and individual level are presented.

The Perfect Target

The Perfect Target PDF
Author: Jenna Mills
Publisher: Silhouette
ISBN: 9781426882647
Size: 67.47 MB
Format: PDF
Category : Fiction
Languages : en
Pages : 256
View: 1604

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Book Description: All Miranda Carrington wanted was to be free from her legendary family's legacy of wealth and power. But even in a little seaside village in Portugal, she could not escape the danger that shadowed her.... Only the sudden, stunning appearance of a dark, mysterious stranger had saved her from the ruthless terrorists stalking her. But was Allessandro Vellenti really the devoted guardian he claimed, or part of the deadly conspiracy swirling around her? She knew she shouldn't trust him--with her life or with her heart. And yet, as she fled with him, she ached to give herself, body and soul, to this man who could be her killer....

A Role For The Let 7 Primary Microrna In Target Gene Recognition And Repression

A Role for the Let 7 Primary MicroRNA in Target Gene Recognition and Repression PDF
Publisher: Stanford University
Size: 36.49 MB
Format: PDF, ePub, Docs
Category :
Languages : en
Pages :
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Book Description: MicroRNA (miRNA) genes produce three noncoding RNA products: the long primary transcript (pri-miRNA), the ~70 nucleotide pre-miRNA, and the ~22-nt mature miRNA. Only the mature miRNA is considered to be the functional species of a miRNA gene in recognizing cognate target mRNAs and modulating their expression. However, mature miRNAs are processed from the primary transcript through sequential endonucleolytic steps. As a result, the mature miRNA sequence is present in all three RNA products of a miRNA gene. It has thus been intrinsically difficult to determine the contribution of each miRNA gene product to target repression. In fact, direct functional roles for pri- and pre-miRNAs have never been ruled out. Here we show that pri- and pre-miRNAs may not be mere transitory intermediates of mature miRNA biogenesis. We found that ectopic expression of the C. elegans miRNA gene let-7 (cel-let-7) in human culture cells results in the production of truncated pre- and mature miRNAs that lack the first two 5' nucleotides, one of which is the first nucleotide of the miRNA seed region (nucleotide SD1). We found this nucleotide to be required for repression of target reporters by cel-let-7 in these cells, demonstrating that pri-let-7 may have a direct role in target repression. Further, we show that the nucleotide sequence and structure of both the pri-/pre-let-7 loop and stem regions play a key role in miRNA gene function in reporter assays. In vitro and in vivo analyses indicated the significance of these regions may be in the mediation of a physical interaction between pri-let-7 and target RNAs. These observations suggest that regulatory information encoded in the structured pri-miRNAs, but absent from mature miRNAs, could be directly interpreted for target recognition and repression through RNA:RNA interaction. Intriguingly, some mutations in the loop nucleotide sequence also restored processing of the 5' ends of C. elegans pre- and mature let-7 in culture cells, demonstrating that the pri-/pre-miRNA loop region can also regulate the precision of mature miRNA biogenesis. Importantly, in the presence of functional pre- and mature let-7, cel-let-7 activity in target repression consists of both SD1-independent and SD1-dependent components, implying potential contributions by both pri- and mature let-7. Finally, we interrogated the effects of pri-/pre-let-7 loop mutations on their ability to rescue a let-7 loss-of-function mutant phenotype in C. elegans. Our results indicate decreased significance of these parameters in the control of worm vulval development, although context-dependent differences in mature miRNA biogenesis between heterologous culture and live animals may partially explain this discrepancy. Taken together the work presented here reveals a novel layer of regulatory complexity encoded in long primary miRNAs that may have broad implications in understanding the mechanisms by which miRNA genes control target expression.

The Mom S Guide To Asperger Syndrome

The Mom s Guide to Asperger Syndrome PDF
Author: Jan Johnston-Tyler
Publisher: AAPC Publishing
ISBN: 9781931282420
Size: 55.53 MB
Format: PDF, Mobi
Category : Education
Languages : en
Pages : 321
View: 7042

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Book Description: he Mom's Guide to Asperger Syndrome and Related Disorders is written primarily for parents of children who have newly been diagnosed with Asperger Syndrome. It is especially a great resource for the preschool through elementary school years. The book draws from the author's personal experience both as the mom of a son with Asperger Syndrome and her study of and work with children and adolescents with special needs. The result is a practical guide, written for other Aspie parents in a clear, concise, and sometimes humorous tone.This user-friendly book leaves no stone unturned, as it explains, in a friendly, familiar voice, situations and issues that all parents with an AS child will encounter at one point or another. Above all else, the book arms parents with basic, sound information empowering them to seek out the very best services and programs for their child.From dealing with sensory issues and bullying to staying on top of homework, The Mom's Guide to Asperger Syndrome and Related Disorders offers easy-to-use suggestions. The Mom's Guide to Asperger Syndrome and related disorders should be used as a practical, valuable reference throughout the years.

Super Skills

Super Skills PDF
Author: Judith Coucouvanis
Publisher: AAPC Publishing
ISBN: 1931282676
Size: 59.36 MB
Format: PDF
Category : Education
Languages : en
Pages : 351
View: 3125

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Book Description: The title says it all! Super Skills: A Social Skills Group Program for Children with Asperger Syndrome, High-Functioning Autism and Related Challenges is SUPER at many levels. Based on a thorough and comprehensive understanding of the unique characteristics of individuals with ASD, Judy Coucouvanis presents 30 lessons grouped under four types of skills necessary for social success: fundamental skills, social initiation skills, getting along with others, and social response skills. Each lesson is highly structured and organized, making it easy for even inexperienced teachers and other group leaders to follow and implement successfully. A series of practical checklists and other instruments provide a solid foundation for assessing students? social skills levels and subsequent planning.

Walking Targets

Walking Targets PDF
Author: B. K. Eakman
ISBN: 0615181228
Size: 67.10 MB
Format: PDF, Mobi
Category : Education
Languages : en
Pages : 304
View: 1691

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Book Description: "An examination of how educators and provocateurs drive a wedge between parents and their children."

Nobody S Perfect

Nobody s Perfect PDF
Author: Madine M. L. Vanderplaat
Publisher: Canadian Government Publishing
Size: 51.52 MB
Format: PDF, Kindle
Category : Child
Languages : en
Pages : 400
View: 2295

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Book Description: In 1980, a joint federal-provincial Regional Health Promotion committee was established to explore ways of working together on a health promotion program that resulted in the Nobody's Perfect program. From October 1986 to June 1987, the Atlantic Region Health Promotion Directorate and the New Brunswick and Newfoundland and Labrador Governments implemented a process and impact evaluation of the program. This report presents the results of the evaluation, including background information; implementation of program delivery; evaluation methodology and limitations; evaluation of the process and its impact; and administrative issues, including costs and time demands and the integration of the program into one-on-one public health programs. Recommendations are included.

Molecular Beacons

Molecular Beacons PDF
Author: Chaoyong James Yang
Publisher: Springer Science & Business Media
ISBN: 3642391095
Size: 55.11 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 194
View: 2485

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Book Description: Molecular Beacons explains working principle of molecular beacons, discusses their design, synthesis, purification and characterization, explores their thermodynamic and kinetic properties, and more importantly, reviews their in vivo and in vitro applications with the emphasis on the design and modification of molecular beacons for in vivo mRNA imaging applications. This book is designed to bring together in a single resource an organized and comprehensive view of molecular beacons and will be a valuable resource for academic, clinical and industrial scientists and graduate students who may consider exploring molecular beacons in their research or practice. Chaoyong James Yang is the Lu Jiaxi Professor of Chemistry at Xiamen University, China. Weihong Tan is a Distinguished Professor of Chemistry and Biomedical Engineering at Hunan University, China and also a University of Florida Distinguished Professor and V. T. and Louis Jackson Professor of Chemistry at the University of Florida, USA.

Oecd Pensions Outlook 2020

OECD Pensions Outlook 2020 PDF
Author: OECD
Publisher: OECD Publishing
ISBN: 9264680160
Size: 77.54 MB
Format: PDF
Category :
Languages : en
Pages : 208
View: 693

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Book Description: The 2020 edition of the OECD Pensions Outlook examines a series of policy options to help governments improve the sustainability and resilience of pension systems.

Starting Points

Starting Points PDF
Author: Jill Hudson
Publisher: AAPC Publishing
ISBN: 9781934575086
Size: 50.56 MB
Format: PDF, Mobi
Category : Education
Languages : en
Pages : 59
View: 5941

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Book Description: Starting from the premise that no two individuals with Asperger Syndrome are the same, Hudson and Myles provide a global perspective of how the core characteristics of AS may appear separately and/or simultaneously, and how they may manifest themselves in a variety of situations. Each characteristic is then paired with a brief explanation, followed by a series of bulleted interventions. Interventions include strategies and visual supports that help children on the spectrum who have difficulty with abstract concepts and thoughts, difficulty understanding and regulating emotions, difficulty recognizing, interpreting, and empathizing with the emotions of others and much more.