Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy

Apoptosis in Cancer Pathogenesis and Anti cancer Therapy PDF
Author: Christopher D. Gregory
Publisher: Springer
ISBN: 3319394061
Size: 40.46 MB
Format: PDF
Category : Medical
Languages : en
Pages : 247
View: 2847

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Book Description: This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Apoptosis In Carcinogenesis And Chemotherapy

Apoptosis in Carcinogenesis and Chemotherapy PDF
Author: George G. Chen
Publisher: Springer Science & Business Media
ISBN: 140209597X
Size: 34.52 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 384
View: 4837

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Book Description: Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

Apoptosis And Cancer Therapy

Apoptosis and Cancer Therapy PDF
Author: Klaus-Michael Debatin
Publisher: Wiley-Blackwell
ISBN:
Size: 10.17 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 1159
View: 5542

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Book Description: Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. Here, a highly distinguished team of authors from top institutes around the world leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.

Programmed Cell Death In Cancer Progression And Therapy

Programmed Cell Death in Cancer Progression and Therapy PDF
Author: Roya Khosravi-Far
Publisher: Springer Science & Business Media
ISBN: 9781402065545
Size: 46.17 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 356
View: 4088

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Book Description: Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

Autophagy And Cancer

Autophagy and Cancer PDF
Author: Hong-Gang Wang
Publisher: Springer Science & Business Media
ISBN: 1461465613
Size: 52.47 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 261
View: 4638

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Book Description: With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

Trends In Stem Cell Proliferation And Cancer Research

Trends in Stem Cell Proliferation and Cancer Research PDF
Author: Rodrigo R. Resende
Publisher: Springer Science & Business Media
ISBN: 9400762119
Size: 53.24 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 661
View: 1482

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Book Description: The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Apoptosis Cell Signaling And Human Diseases

Apoptosis  Cell Signaling  and Human Diseases PDF
Author: Rakesh Srivastava
Publisher: Springer Science & Business Media
ISBN: 1597452009
Size: 56.86 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 384
View: 3881

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Book Description: These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.

Cumulated Index Medicus

Cumulated Index Medicus PDF
Author:
Publisher:
ISBN:
Size: 34.61 MB
Format: PDF, Kindle
Category : Medicine
Languages : en
Pages :
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Book Description:

Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases PDF
Author: Marek Los
Publisher: Springer Science & Business Media
ISBN: 0387236953
Size: 64.76 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 395
View: 173

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Book Description: As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Cell Cycle Checkpoints And Cancer

Cell Cycle Checkpoints and Cancer PDF
Author: Mikhail V. Blagosklonny
Publisher: Eurekah.Com Incorporated
ISBN:
Size: 55.89 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 249
View: 3847

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Book Description: